Are you unknowingly sabotaging your HPLC analyses? The truth is, using the wrong solvent filter can lead to inaccurate results, costly downtime, and even damage to your expensive equipment. HPLC solvent filters, seemingly simple components, are, in fact, critical for maintaining the integrity of your mobile phase and ensuring the longevity of your HPLC system.
High-Performance Liquid Chromatography (HPLC) relies on the meticulous preparation of solvents. The presence of particulate matter, even at microscopic levels, can wreak havoc on the sensitive components of an HPLC system. HPLC solvent filters serve as the first line of defense, removing these contaminants and ensuring a smooth, consistent flow of solvent. Selecting the appropriate filter is not merely a matter of convenience; it's a decision that directly impacts the accuracy, reliability, and lifespan of your chromatographic analyses.
| Topic | Details |
|---|---|
| HPLC Solvent Filters | Devices used to remove particulate matter from HPLC solvents |
| Types of Filters | Solvent inlet filters, syringe filters, membrane disc filters |
| Materials | Polymeric, stainless steel, glass, PEEK polymer, borosilicate glass |
| Pore Sizes | Ranges from 0.05 micron to 20 micron, depending on application |
| Applications | Removing particulate matter, degassing solvents, protecting HPLC columns and pumps |
| Key Manufacturers | Agilent, Restek, Cytiva, among others |
| Benefits of Filtration | Improved HPLC performance, prevention of column clogging, decreased pump downtime, extended column life |
| Solvent Compatibility | Filters must be compatible with a range of solvents, including organic solvents, acids, and alkaline solutions |
| Additional Features | Helium sparge ports, frit designs, color-coded stems for orientation |
| Components of Filtration Kit | Cylindrical tube, filter cartridge, and necessary fittings |
| Link for Reference | Agilent Technologies |
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